Thiyagarajan, Dhivya; Fismen, Silje; Seredkina, Natalya; Jacobsen, Søren; Elung-Jensen, Thomas; Kamper, Anne-Lise; Fenton, Christopher Graham; Rekvig, Ole Petter; Mortensen, Elin Synnøve (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Recent studies demonstrate that transformation of mild lupus nephritis into end-stage disease is imposed by silencing of renal DNaseI gene expression in (NZBxNZW)F1 mice. Down-regulation of DNaseI results in reduced chromatin fragmentation, and in deposition of extracellular chromatin-IgG complexes in glomerular basement membranes in individuals that produce IgG anti-chromatin antibodies. The main ...